Using these cotton toe spacers is a breeze. Simply pick the number of spacers you need according to how many toes you want to separate. Gently place them between your toes. They're great for post - pedicure care or just for daily comfort. As they are disposable, there's no need to clean them. Just throw them away after use. Make sure to keep them in a dry place to maintain their quality. And don't worry about allergic reactions as they are made of pure cotton. If you have any open wounds on your feet, it's best to consult a doctor before using them.